This book has information about the history of Great Silk Road and development of the main routes in Maverannahr in the ancient and medieval epoch. The main attention is paid to the territory of Ustrushana, which situated now within the Uzbekistan, which was in the “shadow” of its distinguished neighbors–Sogd, Chach, and Fergana. This book intended for specialists-archeologists, historians, teachers, guides, and for all who interested with ancient and medieval history of Central Asia.